Microcrystalline Cellulose
Microcrystalline Cellulose
The MICCEL grades of Microcrystalline Cellulose of Ankit Pulps and Boards, are widely accepted excipients by a number of leading pharmaceutical industries in India for its quality, consistency and customer service. Microcrystalline Cellulose revolutionized tableting because of its unique compressibility and carrying capacity. Its exhibits excellent properties as an excipient for solid dosages forms, compact well under minimum compression pressures, has high binding capability and creates tablets that are extremely hard & stable, yet disintegrate rapidly.
Microcrystalline Cellulose
The MICCEL grades of Microcrystalline Cellulose of Ankit Pulps and Boards, are widely accepted excipients by a number of leading pharmaceutical industries in India for its quality, consistency and customer service. Microcrystalline Cellulose revolutionized tableting because of its unique compressibility and carrying capacity. Its exhibits excellent properties as an excipient for solid dosages forms, compact well under minimum compression pressures, has high binding capability and creates tablets that are extremely hard & stable, yet disintegrate rapidly.
Product
MICCEL 101
MICCEL 102
MICCEL 103, MICCEL 112, MICCEL 113
MICCEL 114
MICCEL 105
MICCEL 200, MICCEL 500
MICCEL 301
MICCEL 302
MICCEL 12
MICCEL W, MICCEL WP
MICCEL-102 BD
Wet granulation and direct compressible
Direct compressible & large particle size
Ideal for moisture sensitive material
Directly compressible
Enhanced compressibility with combination
Increase flow ability & Direct compressible
Higher Density, Greater tablet wt.
Direct compressible, Greater tablet wt.
Direct compressible
Wet granulation
Higher density & increase flow
Product
MICCEL 101 – Wet granulation and direct compressible
MICCEL 102 – Direct compressible & large particle size
MICCEL 103, MICCEL 112, MICCEL 113 – Ideal for moisture sensitive material
MICCEL 114 – Directly compressible
MICCEL 105 – Enhanced compressibility with combination
MICCEL 200, MICCEL 500 – Increase flow ability & Direct compressible
MICCEL 301 – Higher Density, Greater tablet wt.
MICCEL 302 – Direct compressible, Greater tablet wt.
MICCEL 12 – Direct compressible
MICCEL W, MICCEL WP – Wet granulation
MICCEL-102 BD – Higher density & increase flow
Tablets Manufacturing – Applications
Process
- A. Direct Compression
- B. Wet Granulation
Advantages
- Chemical purity, binder, disintegrant, flow aid, filler, inertness
- Binder, rapid wicking action, permits fast additional of granulation fluid being most absorbent, most inert
Methods of use
- Table making by direct compression involves only weighing mixing & compressing
Tablets Manufacturing – Applications
Process : Direct Compression
Advantages : Chemical purity, binder, disintegrant, flow aid, filler, inertness
Methods of use : Table making by direct compression involves only weighing mixing & compressing
Process : Wet Granulation
Advantages : Binder, rapid wicking action, permits fast additional of granulation fluid being most absorbent, most inert
Miccel Features
Excellent hardness levels at low compression forces
Low Lubricant sensitivity
Low Tablet Friability
Good Disintegration aid
Super Stability
Performing in Tablets & Capsules Making
| Chemical Purity | Non-reactive Organic ingredient, Extremely Low level of organic & Inorganic |
| Binder | High Hardness level, low friability |
| Disintegrant | Keep Uniform Concentration of drug in solution |
| Flow aid | Require less Lubricant than other typical binders. |
| Inertness | Drug chemical status is maintained. |
| Absorbent | Keeps drugs uniformly mixed. |
Quantum to be used
The amount to be used in direct compression characteristic of the formulation’s other ingredients.
Typical use level is of 15 to 20%
Granulation use level 15%
Levels in excess of 90% has been reported
Co-Processed MCC
Co-processing could lead to formation of excipients with superior quality product compare to the simple physical mixture of their components. Co-processing results in a product with added value related to the ratio of its functionality and price. Development of co-processed directly compressible adjuvant, starts with the selected of the excipients to be combined, their preparation method to get an optimized product with desired physic-chemical parameters.
Co-Processed MCC
Co-processing could lead to formation of excipients with superior quality product compare to the simple physical mixture of their components. Co-processing results in a product with added value related to the ratio of its functionality and price. Development of co-processed directly compressible adjuvant, starts with the selected of the excipients to be combined, their preparation method to get an optimized product with desired physic-chemical parameters.
Grade in house Specification
| Test | MICCEL 101 | MICCEL 102 | MICCEL 103 | MICCEL 112 | MICCEL 113 | MICCEL 114 |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 | NMT 2.0 | NMT 1.5 | NMT 1.5 | * NMT 7.0/NMT 6.0 |
| BD, g/ml | 0.22 to 0.34 | 0.28 to 0.37 | 0.26 to 0.31 | 0.28 to 0.38 | 0.27 to 0.34 | 0.34 to 0.43 |
| + 60 #, % | NMT 1 | NMT 8 | NMT 1 | NMT 8 | NMT 1 | NMT 8 |
| + 200 #, % | NMT 30 | NLT 45 | NMT 30 | NLT 45 | NMT 30 | NLT 40 and NMT 60 |
| Test | MICCEL 301 | MICCEL 302 | MICCEL 102 BD | MICCEL W | MICCEL WP |
|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 |
| BD, g/ml | 0.34 to 0.51 | 0.35 to 0.50 | 0.30 to 0.40 | 0.25 to 0.35 | 0.24 to 0.35 |
| + 60 #, % | NMT 1 | NMT 8 | NMT 8 | NMT 1 | NMT 8 |
| + 200 #, % | NMT 30 | NLT 45 | NLT 50 | NMT 35 | NMT 35 |
| Test | MICCEL 12 | Test | MICCEL 200 | Test | MICCEL 105 | MICCEL 500 |
|---|---|---|---|---|---|---|
| LOD , % | * NMT 7.0/ NMT 6.0 | LOD , % | * NMT 7.0/NMT 6.0 | LOD , % | * NMT 7.0/NMT 6.0 | * NMT 7.0/NMT 6.0 |
| BD, g/ml | 0.25 to 0.37 | BD, g/ml | 0.29 to 0.36 | BD, g/ml | 0.20 to 0.30 | 0.27 to 0.37 |
| + 40 #, % | NMT 1 | + 60 #, % | NLT 10 | + 60 #, % | NLT 50 | |
| +100 #, % | NMT 50 | + 100 #, % | NLT 50 | + 400 #, % | NMT 1 | |
| +325 #, % | NLT 70 |
LOD : Loss on drying, BD: Bulk density
Note : (*) Loss on drying as per IP NMT 6.0 % and as per BP/EP/USP/JP NMT 7.0 %.
Low Moisture Grade
MICCEL 112, MICCEL 113, MICCEL 103.
High Bulk Density Grade
MICCEL 301, MICCEL 302, MICCEL 102 BD.
Directly Compressible Grade
MICCEL 102, MICCEL 102 BD, MICCEL 112, MICCEL 114, MICCEL 200, MICCEL 302.
Wet Granulation
MICCEL 101, MICCEL 105, MICCEL 301, MICCEL W, MICCEL WP.
Superior Flow
MICCEL 200, MICCEL 500.
Super Compatibility
MICCEL 105.
Packaging Details
Available Packaging Type:
HDPE/Paper bags – 25Kg
Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Packaging Details
Available Packaging Type:
1. HDPE/Paper bags – 25Kg
1. Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Unique Features of Microcrystalline Cellulose
Angle of Repose
Customized Bulk Density
Excellent Flowability
Better Compressibility
Frequently Asked Questions
What is Microcrystalline Cellulose (MCC) IP/BP/USP/JP/EP, and what are its key applications in the pharmaceutical industry?
The MCC is a a pure partially depolymerized cellulose, valuable additive in pharmaceutical, food, cosmetic and other industries.
How does Ankit Pulps and Boards ensure the quality and compliance of its MCC products with international pharmacopoeias (IP/BP/USP/JP/EP)?
We have FDA approved inhouse R&D Lab and 100% compliant to regulatory standards.
How can I request samples of Ankit Pulps and Boards' MCC IP/BP/USP/JP/EP for evaluation in our pharmaceutical formulations?
You are just a click away – please share enquiry/sample request on sales@celluloseankit.com.
What are the recommended storage conditions and shelf life for Ankit Pulps and Boards' MCC IP/BP/USP/JP/EP products?
It is recommended to be stored as per pharmacopoeia complied and has shelf life of 5 years from manufacturing date.