Silicified Microcrystalline Cellulose USP
Solution for Optimum Compatability
Silicification of MCC increased physical properties such as true density, Hausner ratio, porosity, ejection force and specific surface area. Other properties such as bulk and tap densities were reduced due to the amorphous and light character of fumed silica.
MICCEL S is the mixture of microcrystalline cellulose and colloidal silicon dioxide (MCC/CSD at 98:2 ratio) and most compactible grade of SMC with flow characteristics similar to doubling the parties size of MCC.
Solution for Optimum Compatability
Silicification of MCC increased physical properties such as true density, Hausner ratio, porosity, ejection force and specific surface area. Other properties such as bulk and tap densities were reduced due to the amorphous and light character of fumed silica.
MICCEL S is the mixture of microcrystalline cellulose and colloidal silicon dioxide (MCC/CSD at 98:2 ratio) and most compactible grade of SMC with flow characteristics similar to doubling the parties size of MCC.
Sr.no. | Test | Specification |
---|---|---|
1 | Description | White or almost white, very fine to moderately fine powder. It is a free-flowing material. |
Solubility | Slightly soluble in sodium hydroxide solution (1 in 20); practically insoluble in water, in acetone, in ethanol, in toluene, and in diluted acid. | |
2 | Identification | |
Test-A (IR Absorption) | Should be comply | |
Test-B | The substance takes on a violet-blue color should be produced. | |
Test-C | A deep yellow color is produced | |
Test-D(silica dispersion uniformity test) | NMT 0.02 | |
3 | Impurities | |
Heavy Metals, µg/g | NMT 10 | |
4 | Specific Tests | |
Residue on Ignition, % | NMT 10 | |
5 | Microbiological Analysis | |
Total Aerobic Microbial Count, CFU/g | NMT 1000 | |
Total Combined Molds and Yeasts Count, CFU/g | NMT100 | |
Escherichia Coli/g | Should be absent | |
Pseudomonas Aeruginosa/g | Should be absent | |
Staphylococcus Aureus/ g | Should be absent | |
Salmonella Species/ 10g | Should be absent | |
6 | Conductivity, µS/cm | NMT 75 |
pH | 5.0 – 7.5 | |
Loss on Drying, % | NMT 7.0 | |
Degree of Polymerization | NMT 350 | |
Bulk Density | Refer chart | |
Particle Size Distribution | Refer chart | |
Water Soluble Substances, % | Should be absent | |
Ether Soluble Substances, % | NMT 0.25 |
Grade Wise In House Specification
Test | MICCEL S-101 | MICCEL S-102 | MICCEL S-102 HD | MICCEL S-112 |
---|---|---|---|---|
Loss on drying (%) | NMT 7.0. | NMT 7.0 | NMT 7.0 | NMT 1.5 |
Bulk Density, g/ml | 0.28 to 0.33 | 0.25 to 0.37 | 0.38 to 0.50 | 0.25 to 0.37 |
% Retention on 60 # | NMT 1 | NMT 8 | NMT 8 | NMT 8 |
% Retention on 200# | NMT 30 | NLT 45 | NLT 45 | NLT 45 |
Packaging Details
Available Packaging Type:
HDPE/Paper bags – 25Kg
Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Packaging Details
Available Packaging Type:
1. HDPE/Paper bags – 25Kg
1. Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Unique Features of Silicified Microcrystalline Cellulose – USP
Angle of Repose
Customized Bulk Density
Excellent Flowability
Better Compressibility
Frequently Asked Questions
What is silicified microcrystalline cellulose, and how is it used in the pharmaceutical industry?
Silicified microcrystalline cellulose is a mixture of microcrystalline cellulose (MCC) and colloidal SiO2 in a 98:2 ratio. It is utilized in the pharmaceutical industry to enhance flowability and ensure uniformity in various formulations.
What sets Ankit Pulps and Boards' silicified microcrystalline cellulose apart from other excipients on the market?
Ankit Pulps and Boards’ silicified microcrystalline cellulose stands out due to the meticulous care taken in its production technology. We use premium quality raw materials to achieve optimum physical properties, including density, Hausner ratio, porosity, and ejection force.
How can I request a sample of your silicified microcrystalline cellulose for testing and evaluation?
Please share enquiry/sample request on sales@celluloseankit.com
Are your pharmaceutical excipients compliant with regulatory standards, such as USP and EP?
Yes, our pharmaceutical excipients are 100% compliant with regulatory standards, including USP and EP. We have an FDA-approved in-house R&D Lab.
What quantities of silicified microcrystalline cellulose do you offer for bulk supply, and how can I place an order?
Bulk quantity order enquiries of 1 MT or above can be placed on sales@celluloseankit.com
Can you provide customized formulations or specifications for your pharmaceutical excipients?
Yes, our proficient technical team is capable of meeting your customization needs.
What is the shelf life of silicified microcrystalline cellulose, and how should it be stored?
Retest date of silicified microcrystalline cellulose is 3 years from the date of manufacturing. It should be stroed in a closed ambient environment.