Sodium & Carboxymethyl Cellulose Sodium CMC
Sodium Carboxymethyl
ellulose (CMC)
Carboxymethyl cellulose, also known as cellulose gum, is a modified form of cellulose. It has carboxymethyl groups attached to some of its sugar-like units that form the cellulose structure. This modified cellulose is commonly used in its sodium form, called sodium carboxymethyl cellulose.
Sodium Carboxymethyl Cellulose (CMC)
Carboxymethyl cellulose, also known as cellulose gum, is a modified form of cellulose. It has carboxymethyl groups attached to some of its sugar-like units that form the cellulose structure. This modified cellulose is commonly used in its sodium form, called sodium carboxymethyl cellulose.
IP | BP | USP | |
Description | A white or almost white, granular powder, odourless or almost odourless, hygroscopic | A white or almost white, granular powder | White to cream colored powder or granules. The powder is hygroscopic. |
Solubility | Insoluble in alcohol, in ether and in most organic solvents | Practically insoluble in acetone, in ethanol and in toluene. It is easily dispersed in water giving colloidal solutions. | Insoluble in alcohol, in ether and in most organic solvent. It is easily dispersed in water forming a colloidal solution |
Identification | |||
Test A | A blue, cotton-like precipitate is produced. | A blue, cotton-like precipitate is formed. | A red-purple color develops at the interface. |
Test B | No precipitate is produced. | No precipitate is produced. | A fine, white precipitated is formed |
Test C | i) A dense white precipitate is formed after addition of potassium antimonite solution. | 1. A dense white precipitate is formed 2. No precipitate is formed. | A dense white precipitate is formed |
Appearance of the solution | Solution A is not more opalescent than the opalescence standard OS4 and not more intensely coloured than reference solution YS6. | Solution S is not more opalescent than the reference suspension III and not more intensely coloured than reference solution Y6. | |
pH | 6.0 to 8.0 | 6.0 to 8.0 | 6.5 to 8.5 |
Arsenic, | NMT 1 ppm | ||
Heavy metals | NMT 20 ppm | ||
Chlorides | NMT 0.25 % | NMT 0.25 % | |
Sulphated ash | 20.0 % to 33.3 % calculated on dried basis. | 20.0 % to 33.3 % calculated on dried basis. | |
Loss on drying | NMT 10.0 % | NMT 10.0 % | NMT 10.0 % |
Assay | Sodium Carboxymethylcellulose contains NLT 6.5 % and NMT 10.8 % of sodium, Na, calculated on dried basis.basis. | NLT 6.5 % and NMT 9.5 % of Na, calculated on the dried basis. | |
Sodium glycollate | Max 0.4% | ||
Viscosity (1% solution on dried basis at 25ºC) | Apparent viscosity 75 % to 140 % of the declared value | 400 to 800 cps 2200 to 4000 cps 6000 to 7500 cps 8000 to 12000 cps |
Microbiological Analysis
Total Aerobic Microbial Count, CFU/g | NMT 1000 | NMT 1000 | NMT 1000 |
Total Combined Yeasts & Molds Count, CFU/g | NMT 100 | NMT 100 | NMT 100 |
Staphylococcus aureus, / g | Should be absent | Should be absent | Should be absent |
Pseudomonas aeruginosa, / g | Should be absent | Should be absent | Should be absent |
Escherichia coli, / g | Should be absent | Should be absent | Should be absent |
Salmonella, /10g | Should be absent | Should be absent | Should be absent |
Uses & Applications
Pharmaceutical Industry
Excipient in Tablet Formulations
CMC is commonly used as an excipient in tablet and capsule formulations. It serves as a binder, disintegrant, and filler. It helps bind the tablet ingredients together, facilitates their disintegration when consumed, and adds bulk to the tablet.
Suspension Stabilizer
CMC is used to stabilize suspensions, ensuring that the solid particles remain uniformly dispersed in the liquid. This is especially important for pharmaceutical suspensions, where accurate dosing and consistency of the active ingredient are crucial.
Viscosity Modifier
CMC can be used to modify the viscosity of liquid formulations, helping to improve their pourability and ease of administration. It is often used in oral syrups and suspensions.
Topical Formulations
In topical formulations such as creams, gels, and ointments, CMC can act as a thickening agent, providing desirable texture and consistency.
Wound Dressings
CMC is used in some wound care products as a component of hydrocolloid dressings. These dressings can absorb exudate from wounds while maintaining a moist environment conducive to healing.
Food Industry
Thickening and Stabilizing Agent
CMC is commonly used as a thickening and stabilizing agent in various food products. It imparts viscosity to liquids and helps prevent ingredient separation in products like salad dressings, sauces, and dairy products.
Gluten-Free Baking
In gluten-free baking, CMC can help improve the texture and moisture retention of baked goods, compensating for the lack of gluten’s binding properties.
Ice Cream and Frozen Desserts
CMC is used in ice cream and frozen dessert formulations to control ice crystal growth and enhance creaminess. It helps prevent the formation of large ice crystals, leading to a smoother texture.
Beverages
CMC is used in some beverages to provide a consistent texture and prevent the settling of suspended particles.
Glazing Agent
In confections, CMC can be used as a glazing agent to provide a glossy appearance and prevent moisture absorption, which helps maintain the quality of the product.
Fat Replacement
CMC can be used as a fat replacement in certain low-fat or reduced-calorie food products, contributing to texture and mouthfeel.
Processed Meats
In processed meats like sausages, CMC can improve the binding of meat particles and enhance moisture retention.
Properties
Molecular Formula
CAS number
9004-32-4
Properties
Molecular Formula – C28H30Na8O27
Molar mass – 250000(Average)
Synonyms – Carboxymethyl cellulose;CMC-Na;cellulose gum;carmellose sodium
CAS number – 9004-32-4
Packaging Details
Available Packaging Type:
HDPE/Paper bags – 25Kg
Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Packaging Details
Available Packaging Type:
1. HDPE/Paper bags – 25Kg
1. Fiberboard/HDPE – 25Kg
*Our standard packaging in 25 Kg bags. We can also customize packaging as per customers request at additional cost
Container
20 Ft. (Approx Wt.)
40 Ft. (Approx Wt.)
Palletized
10,000 Kg
20,000 Kg
Non-Palletized
11,000 Kg
25,000 Kg
Frequently Asked Questions
What are the primary applications of Sodium Carboxymethyl Cellulose (CMC) in the pharmaceutical industry?
Sodium Carboxymethyl Cellulose (CMC) acts as suspension stabilizer which prevents solid particles from settling in liquid suspension.
How does Ankit Pulps and Boards ensure the quality and compliance of its CMC products with relevant pharmacopoeial standards, such as USP and EP?
Ankit Pulps and Boards ensure our quality as we are having entirely automated facility, thereby adhering finished product quality.
How can I request samples of Ankit Pulps and Boards' CMC for testing in our pharmaceutical formulations?
You are just a click away- please share enquiry/sample request on- sales@celluloseankit.com.
How do CMC's rheological properties contribute to the stability and performance of pharmaceutical formulations over time?
CMC contribute to the stability and performance of pharmaceutical formulations maintaining adequate flow properties at high temperature, salinity, and pressure.
What are the recommended storage conditions and shelf life for Ankit Pulps and Boards' CMC products?
To be stored as per pharmacopoeia complied and has shelf life of 5 years from manufacturing date.
How does CMC contribute to the overall performance and stability of pharmaceutical formulations over time?
CMC can protect the energy-stable disulfide bond in gluten protein from being destroyed by salt.